Evaluation Report Immunological Faecal Occult Blood Tests
(NHS Purchasing and Supply Agency)
Evaluation Report - Immunological Faecal Occult Blood Tests (PDF 1.7Mb)
Immunological faecal occult blood tests (iFOBT) use antibodies raised against human haemoglobin (hb) to detect blood present in faeces. The presence of blood in a faecal sample can be used as a marker to detect significant neoplasia in otherwise asymptomatic people.
iFOBT have the potential to be used in bowel cancer screening programmes. They are more sensitive and specific than the current guaiac-based faecal occult blood tests and can be automated.
In this report data are presented for imprecision, linearity, the effect of antigen excess, carryover and haemoglobin variants for three automated analytical iFOBT methods.
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